Italy manager Roberto Mancini said watching three years of hard work come to fruition with Euro 2020 glory on Sunday reduced him to tears at Wembley after his side edged England on penalties.
Shakhtar dominated possession as expected but were toothless up front and Inter opened the scoring with their first chance after 19 minutes.
Italy are back and they have a point to prove.
Photos from soccer matches played across top European Leagues on Saturday.
RB Leipzig defender Josko Gvardiol powered home a towering header in 70th-minute to earn them a 1-1 draw against visitors Manchester City in their Champions League Round of 16 first leg.
Atletico celebrate anniversary with 3-1 comeback win over Mallorca
The old guard, once again, came good for Italy, this time steering the Azzurri to Euro 2020 glory, but wily defensive stalwarts Leonardo Bonucci and Giorgio Chiellini cannot go on forever.
Martinez struck inside two minutes before Domenico Berardi equalised, but Lukaku gave Inter breathing space with a powerful strike and a penalty before half time.
A round-up of Saturday's action in La Liga, Ligue 1 and Serie A.
A summary of Saturday night's matches in the Euro 2020 qualifiers.
Spain and Portugal played out an entertaining 0-0 draw on Friday as both sides prepared for this month's European Championship.
Images from the UEFA Champions League matches played on Tuesday night.
IMAGES from the football matches played across Europe on Sunday.
Images from UEFA Champions League matches played on Wednesday.
Mourinho's side failed to turn their domination into more goals and things got edgy late on when Saville's shot evaded Gazzaniga who seemed slow to get down.
Images from football matches played in Europe on Sunday.
LaLiga leaders Barcelona's pursuit of a 27th Spanish title gained momentum after a 2-1 comeback win over Real Madrid.
Lorenzo Insigne curled a quite wonderful shot beyond the reach of Belgium goal-keeper Thibaut Courtois after jinking in from the left flank.
IMAGES from soccer matches played across Europe on Sunday.
Moments to remember from the quarter-finals.
Images from the Champions League matches played across Europe on Tuesday
Barcelona teenager Ansu Fati scored twice to lead his side to a 2-1 win at home to Levante on Sunday, finding the net in a league game for the first time in more than four months and becoming the youngest player to net a La Liga double. Romelu Lukaku scored a quickfire second-half double to give Inter Milan a 2-0 win at Udinese on Sunday, ending their run of three successive 1-1 league draws.
Images from soccer matches played across Europe on Saturday.
Former Real youth player Joselu pulled a goal back for Alaves in the 59th minute, powering in a header from a free kick, but Benzema rounded off the victory for second-placed Real with an exquisite solo run and goal in the 70th minute.
A round-up of Saturday's action in LaLiga, Ligue 1 and Serie A.
Real Madrid's teenage Brazilian duo Vinicius Junior and Rodrygo Goes sent them top of La Liga as both scored in a 2-0 win over Osasuna on Wednesday.
Images from football action around European leagues played on Sunday
News of all that's transpired on and off the football field
Images from the Euro 2020 Qualifiers played on Monday
A round-up of Tuesday's action in the UEFA Champions League.
A round-up of Wednesday's action in the UEFA Champions League.
Liverpool thrashed Atalanta 5-0, Real Madrid boosted their chances of reaching the Champions League knockout stages with a 3-2 home victory over Inter Milan and Bayern Munich came from behind to crush RB Salzburg 6-2.
France stretched their unbeaten run against Croatia to eight games after a late goal by Kylian Mbappe gave the world champions a 2-1 win in their Nations League top-tier Group 3 match on Wednesday.
The victory saw the unfashionable Madrid club tighten their grip on the coveted fourth spot in the table by moving on to 58 points after 36 games, three points clear of nearest challengers Sevilla, who lost to Leganes on Friday.
Inter will be his sixth club in a career which began when he made his debut for Anderlecht as a 16-year-old and has taken him to Chelsea, West Bromwich Albion and Everton.
A round-up of Wednesday's action in the UEFA Champions League.
Images from the FIFA World Cup qualifiers matches.
Valverde said he was concerned about the team's away form after they were comprehensively beaten 2-0 by promoted Granada
News of all that's transpired on and off the football field
Sergio Ramos equalled Iker Casillas's record of 167 appearances for Spain on an emotional night at Sporting Gijon's El Molinon stadium, which paid tribute to the late Spain and Sporting forward Quini before kickoff.